Ensaios Clínicos Duplo Cego Randomizados Sobre a Utilização Do Gengibre no Tratamento da Dor – Uma Revisão Integrativa.

Abstract

Ginger is used all over the world in the prevention and treatment of diseases, thanks to its properties, its therapeutic effects have been known for millennia, playing an important role in folk medicine. Ginger has an effect on reducing and modulating pain mechanisms, such as inhibition of prostaglandins by COX and LOX pathways, antioxidant activity, inhibition of transcription factor NFkB or vanilloid nociceptor agonist. This integrative review aims to summarize the randomized clinical trials (RCTs) published over the last 10 years, in which ginger has traditionally been used as an analgesic and anti-inflammatory for dysmenorrhea, late-onset muscle pain (DMIT), knee osteoarthritis (OA ), chronic low back pain (CLBP), migraine and pain from burns. The selection of scientific articles in Portuguese and English was carried out in the MEDLINE-PubMed database, using the keywords “Zingiber”, “Ginger”, “pain” with the Boolean operator AND to establish the logical relationship between them, together with with the Randomized Controlled Trial search filter selecting, including only human studies. The use of both oral and topical ginger proved to be efficient, safe and promising, the studies were unanimous in indicating the anti-inflammatory, cytokine and PG inhibitory action in inflammation and pain. The therapeutic benefits of ginger need to be interpreted with caution since the number of trials, low methodological quality, high population variation between studies is still limiting. New multicentric RCTs in different populations, with adequate numbers of patients, standardization of dosages and compounds are important to confirm the results of this review.